abstract：BACKGROUND:Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad ...

journal_title：Journal of neuroinflammation

authors： Rutar M,Natoli R,Chia RX,Valter K,Provis JM

更新日期：2015-01-17 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial disorder associated with the accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into plaques. One of the major contributors to neuronal death is chronic and uncontrolled inflammatory activation of microglial cells around the plaques a...

journal_title：Journal of neuroinflammation

authors： Malm T,Mariani M,Donovan LJ,Neilson L,Landreth GE

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Microglia/macrophages (MG/MΦ) are found in the subretinal space in both mice and humans. Our goal was to study the spatial and temporal distribution, the phenotype, and gene expression of subretinal MG/MΦ in mice with normal retinas and compare them to mice with known retinal pathology. METHODS:We studied C...

journal_title：Journal of neuroinflammation

authors： Aredo B,Zhang K,Chen X,Wang CX,Li T,Ufret-Vincenty RL

更新日期：2015-01-15 00:00:00

abstract：:Toll like receptor 4 (TLR4) is an innate immune pattern recognition receptor, expressed predominantly on microglia in the CNS. Activation of spinal TLR4 plays a critical role in the genesis of pathological pain induced by nerve injury, bone cancer, and tissue inflammation. Currently, it remains unknown how synaptic ac...

journal_title：Journal of neuroinflammation

authors： Yan X,Jiang E,Weng HR

更新日期：2015-01-09 00:00:00

abstract：:The excitotoxin quinolinic acid, a by-product of the kynurenine pathway, is known to be involved in several neurological diseases including multiple sclerosis (MS). Quinolinic acid levels are elevated in experimental autoimmune encephalomyelitis rodents, the widely used animal model of MS. Our group has also found pat...

journal_title：Journal of neuroinflammation

authors： Sundaram G,Brew BJ,Jones SP,Adams S,Lim CK,Guillemin GJ

更新日期：2014-12-13 00:00:00

abstract：:We report on a serum autoantibody associated with cerebellar ataxia. Immunohistochemical studies of sera from four patients referred for autoantibody testing revealed binding of high-titer (up to 1:5,000) IgG antibodies, mainly IgG1, to the molecular layer, Purkinje cell layer, and white matter on mouse, rat, porcine,...

journal_title：Journal of neuroinflammation

authors： Jarius S,Scharf M,Begemann N,Stöcker W,Probst C,Serysheva II,Nagel S,Graus F,Psimaras D,Wildemann B,Komorowski L

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Some children with autism spectrum disorders (ASD) are characterized by fluctuating behavioral symptoms following immune insults, persistent gastrointestinal (GI) symptoms, and a lack of response to the first-line intervention measures. These children have been categorized as the ASD-inflammatory subtype (AS...

journal_title：Journal of neuroinflammation

authors： Jyonouchi H,Geng L,Davidow AL

更新日期：2014-10-27 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways is a useful therapeut...

journal_title：Journal of neuroinflammation

authors： Jiang M,Li J,Peng Q,Liu Y,Liu W,Luo C,Peng J,Li J,Yung KK,Mo Z

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Plasminogen activation is a ubiquitous source of fibrinolytic and proteolytic activity. Besides its role in prevention of thrombosis, plasminogen is involved in inflammatory reactions in the central nervous system. Plasminogen has been detected in the cerebrospinal fluid (CSF) of patients with inflammatory d...

journal_title：Journal of neuroinflammation

authors： Mezzapesa A,Orset C,Plawinski L,Doeuvre L,Martinez de Lizarrondo S,Chimienti G,Vivien D,Mansour A,Matà S,Pepe G,Anglés-Cano E

更新日期：2014-09-16 00:00:00

abstract：BACKGROUND:Low testosterone and obesity are independent risk factors for dysfunction of the nervous system including neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we investigate the independent and cooperative interactions of testosterone and diet-induced obesity on metabolic, inflammator...

journal_title：Journal of neuroinflammation

authors： Jayaraman A,Lent-Schochet D,Pike CJ

更新日期：2014-09-16 00:00:00

abstract：:Similar to peripheral immune/inflammatory cells, neuroglial cells appear to rely on calcineurin (CN) signaling pathways to regulate cytokine production and cellular activation. Several studies suggest that harmful immune/inflammatory responses may be the most impactful consequence of aberrant CN activity in glial cell...

journal_title：Journal of neuroinflammation

authors： Furman JL,Norris CM

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the prese...

journal_title：Journal of neuroinflammation

authors： Jose S,Tan SW,Ooi YY,Ramasamy R,Vidyadaran S

更新日期：2014-09-03 00:00:00

abstract：:Chronic inflammation has been shown to contribute to the development of a wide variety of disorders by means of a number of proposed mechanisms. Depression and cognitive impairment are two such disorders which may share a closely linked inflammatory etiology. The ability of inflammatory mediators to alter the activity...

journal_title：Journal of neuroinflammation

authors： Allison DJ,Ditor DS

更新日期：2014-09-02 00:00:00

abstract：:Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant importance in regulating the damage/repair balance after injury. The role of macrophages in such nervous system lesi...

journal_title：Journal of neuroinflammation

authors： Neirinckx V,Coste C,Franzen R,Gothot A,Rogister B,Wislet S

更新日期：2014-08-28 00:00:00

abstract：:Microglia are the primary immunocompetent cells in brain tissue and microglia-mediated inflammation is associated with the pathogenesis of various neuronal disorders. Recently, many studies have shown that mesenchymal stem cells (MSCs) display a remarkable ability to modulate inflammatory and immune responses through ...

journal_title：Journal of neuroinflammation

authors： Liu Y,Zhang R,Yan K,Chen F,Huang W,Lv B,Sun C,Xu L,Li F,Jiang X

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:Genetic and environmental factors are critical elements influencing the etiology of major depression. It is now accepted that neuroinflammatory processes play a major role in neuropsychological disorders. Neuroinflammation results from the dysregulation of the synthesis and/or release of pro- and anti-inflam...

journal_title：Journal of neuroinflammation

authors： Cazareth J,Guyon A,Heurteaux C,Chabry J,Petit-Paitel A

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Activation of hyaluronic acid (HA) and associated enzyme synthesis has been demonstrated in experimental stroke animal models. Our study aimed to investigate the plasma levels of HA in acute stroke patients and the associations between HA levels and functional outcome. METHODS:This was a multicenter case-co...

journal_title：Journal of neuroinflammation

authors： Tang SC,Yeh SJ,Tsai LK,Hu CJ,Lien LM,Peng GS,Yang WS,Chiou HY,Jeng JS

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is a pharmacologic agent inducing neutrophil mobilization and a new candidate for neuroprotection and neuroregeneration in stroke. Its effects when used in combination with tissue plasminogen activator (tPA) were explored during the acute phase of ischemic stroke...

journal_title：Journal of neuroinflammation

authors： Gautier S,Ouk T,Tagzirt M,Lefebvre C,Laprais M,Pétrault O,Dupont A,Leys D,Bordet R

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury a...

journal_title：Journal of neuroinflammation

authors： Vasconcelos AR,Yshii LM,Viel TA,Buck HS,Mattson MP,Scavone C,Kawamoto EM

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Pro-inflammatory cytokines are known to have deleterious effects on Schwann cells (SCs). Interleukin 17 (IL-17) is a potent pro-inflammatory cytokine that exhibits relevant effects during inflammation in the peripheral nervous system (PNS), and IL-17-secreting cells have been reported within the endoneurium ...

journal_title：Journal of neuroinflammation

authors： Stettner M,Lohmann B,Wolffram K,Weinberger JP,Dehmel T,Hartung HP,Mausberg AK,Kieseier BC

更新日期：2014-03-29 00:00:00

abstract：BACKGROUND:Spinal cord ischemia-reperfusion (I/R) involves two-phase injury, including an initial acute ischemic insult and subsequent inflammatory reperfusion injury, resulting in blood-spinal cord barrier (BSCB) dysfunction involving the TLR₄ pathway. However, the correlation between TLR₄/MyD₈₈-dependent and TLR₄/TRI...

journal_title：Journal of neuroinflammation

authors： Li XQ,Lv HW,Tan WF,Fang B,Wang H,Ma H

更新日期：2014-03-28 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with po...

journal_title：Journal of neuroinflammation

authors： Zhu HT,Bian C,Yuan JC,Chu WH,Xiang X,Chen F,Wang CS,Feng H,Lin JK

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:HIV-infected individuals are at an increased risk of developing neurological abnormalities. HIV induces neurotoxicity by host cellular factors and individual viral proteins. Some of these proteins including viral protein R (Vpr) promote immune activation and neuronal damage. Vpr is known to contribute to cel...

journal_title：Journal of neuroinflammation

authors： Torres L,Noel RJ Jr

更新日期：2014-03-22 00:00:00

abstract：BACKGROUND:Paroxetine, a selective serotonin reuptake inhibitor for counteracting depression, has been recently suggested as having a role in prevention of dopaminergic neuronal degeneration in substantia nigra, a hallmark of Parkinson's disease (PD). The pathogenesis of this type of neurological disorders often involv...

journal_title：Journal of neuroinflammation

authors： Liu RP,Zou M,Wang JY,Zhu JJ,Lai JM,Zhou LL,Chen SF,Zhang X,Zhu JH

更新日期：2014-03-12 00:00:00

abstract：BACKGROUND:Meningothelial cells (MECs) are the cellular components of the meninges. As such, they provide important barrier function for the central nervous system (CNS) building the interface between neuronal tissue and the cerebrospinal fluid (CSF), and are also part of the immune response of the CNS. METHODS:Human,...

journal_title：Journal of neuroinflammation

authors： Li J,Fang L,Meyer P,Killer HE,Flammer J,Neutzner A

更新日期：2014-02-24 00:00:00

abstract：:Oral atorvastatin has prevented or reversed paralysis in the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE), and reduced development of new MS lesions in clinical trials. Besides inhibiting development of encephalitogenic T cells, atorvastatin treatment of EAE has been associated with an...

journal_title：Journal of neuroinflammation

authors： Weber MS,Prod'homme T,Youssef S,Dunn SE,Steinman L,Zamvil SS

更新日期：2014-02-06 00:00:00

abstract：BACKGROUND:Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/ CX3C chemokine receptor 1 (CX3CR1) signaling is important in modulating the communication between neurons and resident microglia/migrated macrophages in the central nervous system (CNS). Although CX3CR1 deficiency is associated with an improved outcome following is...

journal_title：Journal of neuroinflammation

authors： Tang Z,Gan Y,Liu Q,Yin JX,Liu Q,Shi J,Shi FD

更新日期：2014-02-03 00:00:00

abstract：BACKGROUND:In neuroinflammatory diseases, macrophages can play a dual role in the process of tissue damage, depending on their activation status (M1 / M2). M1 macrophages are considered to exert damaging effects to neurons, whereas M2 macrophages are reported to aid regeneration and repair of neurons. Their migration w...

journal_title：Journal of neuroinflammation

authors： Vogel DY,Heijnen PD,Breur M,de Vries HE,Tool AT,Amor S,Dijkstra CD

更新日期：2014-02-01 00:00:00

abstract：:Although neuroinflammation has been studied extensively in animal models of cerebral ischemia, their contrasting functions are still not completely understood. A major participant in neuroinflammation is microglia and microglial activation usually regulated by the chemokine CX3CL1 (fractalkine) and its receptor, CX3CR...

journal_title：Journal of neuroinflammation

authors： Briones TL,Woods J,Wadowska M

更新日期：2014-01-22 00:00:00

abstract：:Although major depressive disorder imposes a serious public health burden and affects nearly one in six individuals in developed countries over their lifetimes, there is still no consensus on its pathophysiology. Inflammation and cytokines have emerged as a promising new avenue in depression research, and, in particul...

journal_title：Journal of neuroinflammation

authors： Bloom J,Al-Abed Y

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Several lines of evidence suggest that CCL2 could initiate the hyperalgesia of neuropathic pain by causing central sensitization of spinal dorsal horn neurons and facilitating nociceptive transmission in the spinal dorsal horn. The cellular and molecular mechanisms by which CCL2 enhances spinal pain transmis...

journal_title：Journal of neuroinflammation

authors： Huang CY,Chen YL,Li AH,Lu JC,Wang HL

更新日期：2014-01-10 00:00:00

abstract：OBJECTIVES:The neurological basis for autism is still not fully understood, and the role of the interaction between neuro-inflammation and neurotransmission impairment needs to be clearer. This study aims to test the possible association between impaired levels of gamma aminobutyric acid (GABA), serotonin, dopamine, ox...

journal_title：Journal of neuroinflammation

authors： Alabdali A,Al-Ayadhi L,El-Ansary A

更新日期：2014-01-08 00:00:00

abstract：BACKGROUND:Interleukin-1 (IL-1) is a key mediator of ischaemic brain injury induced by stroke and subarachnoid haemorrhage (SAH). IL-1 receptor antagonist (IL-1Ra) limits brain injury in experimental stroke and reduces plasma inflammatory mediators associated with poor outcome in ischaemic stroke patients. Intravenous ...

journal_title：Journal of neuroinflammation

authors： Singh N,Hopkins SJ,Hulme S,Galea JP,Hoadley M,Vail A,Hutchinson PJ,Grainger S,Rothwell NJ,King AT,Tyrrell PJ

更新日期：2014-01-03 00:00:00

abstract：BACKGROUND:White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflamm...

journal_title：Journal of neuroinflammation

authors： Weaver-Mikaere L,Gunn AJ,Mitchell MD,Bennet L,Fraser M

更新日期：2013-12-17 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV) continues to be one of the most prevalent global health afflictions to date. The advent and introduction of combined antiretroviral therapy (cART) has made a significant impact on the course of infection. However, as patients are living longer, many HIV-associated illnesses ar...

journal_title：Journal of neuroinflammation

authors： Davidson DC,Jackson JW,Maggirwar SB

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disorder characterized by selective motor neuron death in the spinal cord, brainstem, and motor cortex. Neuroinflammation is one of several pathological causes of degenerating motor neurons and is induced by activated microgl...

journal_title：Journal of neuroinflammation

authors： Cai M,Choi SM,Song BK,Son I,Kim S,Yang EJ

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Aging and neurodegenerative disease predispose to delirium and are both associated with increased activity of the innate immune system resulting in an imbalance between pro- and anti-inflammatory mediators in the brain. We examined whether hip fracture patients who develop postoperative delirium have altered...

journal_title：Journal of neuroinflammation

authors： Westhoff D,Witlox J,Koenderman L,Kalisvaart KJ,de Jonghe JF,van Stijn MF,Houdijk AP,Hoogland IC,Maclullich AM,van Westerloo DJ,van de Beek D,Eikelenboom P,van Gool WA

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS); however, a comprehensive examination of complement expression in this disease has not been performed. This study therefore aimed to determine the expression of complement compone...

journal_title：Journal of neuroinflammation

authors： Lee JD,Kamaruzaman NA,Fung JN,Taylor SM,Turner BJ,Atkin JD,Woodruff TM,Noakes PG

更新日期：2013-09-26 00:00:00

abstract：BACKGROUND:Highly active antiretroviral therapy (HAART) restores inflammatory immune responses in AIDS patients which may unmask previous subclinical infections or paradoxically exacerbate symptoms of opportunistic infections. In resource-poor settings, 25% of patients receiving HAART may develop CNS-related immune rec...

journal_title：Journal of neuroinflammation

authors： Mutnal MB,Schachtele SJ,Hu S,Lokensgard JR

更新日期：2013-07-31 00:00:00

abstract：AIM:To determine whether Compound 49b, a novel beta-adrenergic receptor agonist, can prevent increased inflammation and apoptosis in mice after exposure to ocular blast. METHODS:Eyes of C57/BL6 mice were exposed to a blast of air from a paintball gun at 26 psi (≈0.18 MPa). Eyes were collected 4 hours, 24 hours, and 72...

journal_title：Journal of neuroinflammation

authors： Jiang Y,Liu L,Pagadala J,Miller DD,Steinle JJ

更新日期：2013-07-30 00:00:00